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Learn about the potential side effects of iron protein succinylate. Includes common and rare side effects information for consumers and healthcare professionals. Name: Iron protein succinylate; Accession Number: DB; Type: Small Molecule; Groups: Approved, Investigational; Description: Not. View pharmacology details for the Iron protein succinylate generic medicine.

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J Pharm Pharmacol Jun;43 6: A product containing a high amount of iron and maintaining all the necessary characteristics of stability and solubility for a drug can be prepared by succinylating the proteins, in the specific case the milk proteins, before the reaction with the iron salt.

A child allergic to cow’s milk developed a mild systemic allergic reaction after the first dose of Ferplex proetin iron proteinsuccinylate. With this medication, 63 patients Iron protein succinylate is a new iron preparation for oral administration. The authors review the relevant literature and report a case of Toxic Epidermal Necrolysis Syndrome where two medications, iron protein succinylate and dabigatran, not previously associated with the disorder might have acted as precipitants to it.

Iron protein succinylate in the treatment of iron deficiency: A trivalent iron protein complex has been developed using an N-acetyl-aspartylated derivative of casein Fe-ASP for oral iron therapy. Iron protein succinylate is an iron-protein complex, in which iron is present in ferric form.

Iron protein succinylate

Hum Exp Toxicol Mar;22 3: The first aim of this meta-analysis is to verify the increase of hemoglobin Hb in these patients treated with ITF, treated with iron sulphate and treated with iron-polysterene sulphonate. The ITF absorption process, like that of ferritin, proceeds along the physiological pathways without bypassing the transfer system of the intestinal mucosal cells since no further increase of serum irin is observed when giving high doses of ITF to the rat pretreated with a saturating dose of ferrous sulphate.


R Bracchitta G Santoni. Clin Drug Investig ;25 ITF, a soluble iron succinyl-protein complex, orally administered to the rat elevates the concentration of iron in the serum to a greater extent than ferritin.

Iron protein succinylate – DrugBank

In 6 fasting, conscious dogs, fitted with 8 bipolar electrodes and 3 strain-gauge force transducers along the gastrointestinal tract, gastrointestinal motor activity was recorded. Serum iron curves were determined in two groups of iron deficient patients after oral administration of iron protein succinylate or ferritin.

A second group of iron deficient patients with no anti Succiynlate concurrent treatment were admitted to the same iron treatment, lasting 60 days. The main property of the derivative is to keep iron bonded at acidic pH values. Pharmacol Toxicol Sep;87 3: This paper provides an overview of the pharmacokinetic and clinical data on Fe-ASP use. Recovery from energy metabolism derangement of the hepatic tissue by iron therapy.

Iron Protein Succinylate

Iron derivatives of modified milk protein. Multicentre, double blind, randomised clinical trial. Some of the brands for iron protein succinylate might be better known than iron protein succinylate itself.

The succinylatf iron increase induced by ITF is delayed succinylafe compared with ferrous sulphate. Five hundred and forty-nine patients received ITF ; patients were treated with ferrous sulphate. Electronic databases – Medline, the Cochrane Library, and Embase were searched for studies published up to January Histological damage to the gastroduodenal mucosa was evaluated using light and electron microscopy.

Controlled, double-blind, multicenter clinical trial of iron protein succinylate in the treatment succiylate iron deficiency in children. It has been developed for oral iron-supplementation therapy and is characterized by a very favorable succinylahe profile. To evaluate the efficacy and safety of iron protein succinylate IPS oral solution in preventing and treating anemia of prematurity AOP. The increase induced by iron protein succinylate was more prolonged than that of ferritin.


Safety and usefulness of intravenous iron sucrose in the management of preoperative anemia in patients with menorrhagia: A systematic review was conducted to analyze the tolerability of several oral iron supplements based on data obtained in available publications and to report the incidence of adverse effects AEs for each supplement both overall and gastrointestinal. Total infusion of low molecular weight iron-dextran for treating postpartum anemia.

The effects of iron protein succinylate ITFan iron complex insoluble under acid conditions, and ferrous sulfate were studied in the rat.

In this brief review the preclinical safety studies on iron protein succinylate synonym: What Is Known And Objective: B Manfredi F Finelli. Pharmacological and toxicological studies on an iron succinyl-protein complex ITF for oral treatment of iron deficiency anemia. G Landucci S Frontespezi. S Scremin L Caprioglio. To assess gastroduodenal mucosal damage and the potential protective effect of different antianaemic preparations, a study was carried out to compare the gastroduodenal toxicity caused by three different types of antianaemic drugs in normal and anaemic rats administered at repeated therapeutic doses.

Overview of clinical trials in the treatment of iron deficiency with iron-acetyl-aspartylated casein. The absorption of iron from iron succinyl-protein complexes was investigated in mice.

Flavio Lazzari Maria Carrara. Iron protein succynilate in the treatment of iron deficiency: Clinical or observational studies reporting data on the tolerability of oral iron supplements were included.